Prof. Dr. Steffen Jung
Title: "Probing brain macrophage functions"
Born in Homburg/ Saar, Germany, Steffen Jung began his undergraduate studies at the University of Bonn, and then moved to Cologne, where he performed his Ph.D. in the Institute of Genetics headed by Klaus Rajewsky under the guidance of Andreas Radbruch. Specifically, he used the then newly introduced gene targeting technology to define cis-acting control elements driving non-coding 'sterile' transcripts in immunoglobulin class switch recombination. In 1993, Steffen moved for post-doctoral training to Israel and joined the laboratory of Yinon Ben-Neriah at the Lautenberg Center (Hebrew University, Jerusalem) studying transcription factors and kinases in T cell signaling. In 1997, Steffen went to New York for a post-doc in the laboratory of Dan Littman at the Skirball Institute for Molecular Pathogenesis, NYU Medical Center. His studies there focused on the chemokine receptor CX3CR1 and its membrane-tethered ligand CX3CL1/ fractalkine, specifically, he generated CX3CR1gfp reporter mice. In 2002, Steffen returned to Israel and joined the faculty of the Department of Immunology at the Weizmann Institute, where he received tenure in 2009 and full professorship in 2015. Current work of the Jung lab aims at elucidating in vivo aspects of mononuclear phagocytes, including developmental pathways and differential functions of monocytes, DC and macrophages. Specifically, the team applies intra-vital imaging, conditional cell and gene ablation, and precursor graft-mediated reconstitution, combined with advanced genomic analysis to investigate the biology of these cells in physiological health and disease context. Recent focus is given to the study of monocyte-derived intestinal macrophages, brain macrophages including microglia and CNS-border associated macrophages, as well as the role of nerve-associated macrophages and their involvement in metabolic disorders.