Acknowledgement:

This project has received funding from the European Union´s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 813294 (ENTRAIN).

2024

Wenzel J, Schwaninger M. Macrophages and endothelial cells in the neurovascular unit. Acta Neuropathol. 2024 Feb 12, Vol 147, No 36. doi: 10.1007/s00401-024-02697-y

Dalmau Gasull A, Glavan M, Reddy Samawar SK, Kapupara K, Kelk J, Rubio M, Fumagalli S, Sorokin L, Vivien D, Prinz M. The niche matters: origin, function and fate of CNS-associated macrophages during health and disease. Acta Neuropathol. 2024 Feb 12, Vol 147 No 37. doi:10.1007/s00401-023-02676-9

Denes A, Hansen CE, Oezorhan U, Figuerola S, de Vries HE, Sorokin L, Planas AM, Engelhardt B, Schwaninger M. Endothelial cells and macrophages as allies in the healthy and diseased brain. Acta Neuropathol. 2024 Feb 12, Vol 147, No 38. doi: 10.1007/s00401-024-02695-0.

Wu Y-C Wu, Bogale TA, Koistinaho J, Pizzi M, Rolova T, Bellucci A. The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders. Acta Neuropathol. 2024 Feb 12, Vol 147, No 39. doi: 10.1007/s00401-024-02696-z.

 

2023

De Paola M, Pischiutta F, Comolli D, Mariani A, Kelk J, Lisi I, Cerovic M, Fumagalli S, Forloni G, Zanier E R. Neural cortical organoids from self-assembling human iPSC as a model to investigate neurotoxicity in brain ischemia, J Cereb Blood Flow Metab., 2023 Jan 18, doi: 10.1177/0271678X231152023

2022

Engelender S, Stefanis L, Oddo S, Bellucci A. Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?, Mov Disord., 2022 May 17, Vol 37, No 7, pp. 1346-1359, doi: 10.1002/mds.29058

Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Pahutan Bosch L F, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch K-P, Lämmermann T, Priller J, Kierdorf K, Prinz M. Specification of CNS macrophage subsets occurs postnatally in defined niches, Nature, 2022 Apr 20, Vol 604, pp. 740-748, doi: 10.1038/s41586-022-04596-2

Louet E R, Glavan M, Orset C, Parcq J, Hanley D F, Vivien D. tPA-NMDAR Signaling Blockade Reduces the Incidence of Intracerebral Aneurysms, Transl Stroke Res., 2022 Mar 21, Vol 13, pp.1005-1016, doi: 10.1007/s12975-022-01004-9

Császár  E, Lénárt N, Cserép C,  Környei Z,  Fekete R,  Pósfai B, Balázsfi D,  Hangya B, Schwarcz  A D, Szabadits E, Szöllősi D, Szigeti K, Máthé D, Brian L. West B L, Sviatkó K, Brás A R, Jean-Charles Mariani J-C, Kliewer A, Lenkei Z, Hricisák L, Benyó Z, Baranyi M, Sperlágh B, Menyhárt Á, Farkas E, Dénes Á. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions, J Exp Med., 2022 Feb 24, Vol 219, No 3, doi: 10.1084/jem.20211017

2021

Wevers N R, Lekshmi Nair A, Fowke T M, Pontier M, Kasi D G, Spijkers X M, Hallard C, Rabussier G, van Vught R, Vulto P, de Vries E H, Lanz H L. Modeling ischemic stroke in a triculture neurovascular unit on-a-chip. Fluids Barriers CNS, 2021 Dec 14, 18, 59. doi: 10.1186/s12987-021-00294-9

Tóth E Á, Turiák L, Visnovitz T, Cserép C, Mázló A, Sódar B W, Försönits A I, Petővári G, Sebestyén A, Komlósi Z, Drahos L, Kittel Á, Nagy G, Bácsi A, Dénes Á, Gho Y S,  Szabó-Taylor K É, Buzás E I. Formation of a protein corona on the surface of extracellular vesicles in blood plasma. J Extracell Vesicles, 2021 Sep 14, Vol 10, Issue 11. doi: 10.1002/jev2.12140

Wenzel*, J., Lampe*, J., Müller-Fielitz*, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özörhan, Ü., Neve, V., Wagner, J.U.G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., Sauve, F., Fernando Ferreira Coelho, C., Franz, J., Spieker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villasenor, R., Jöhren, O., Altmeppen, H.C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R. Hilgenfeld, R., Glatzel, M., Prevot, V., Schwaninger, M. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci 24, 1522–1533 (2021). doi: 10.1038/s41593-021-00926-1. *contributed equally

Bogale T A, Faustini G, Longhena F, Mitola S, Pizzi M, Bellucci A. Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives. Front Immunol., 2021 Feb 19, Vol. 12, 611761. doi: 10.3389/fimmu.2021.611761

2020

Gallizioli M, Miró-Mur F, Otxoa-de-Amezaga A, Cugota R, Salas-Perdomo A, Justicia C, Brait V H, Ruiz-Jaén F, Arbaizar-Rovirosa M, Pedragosa J, Bonfill-Teixidor E, Gelderblom M, Magnus T, Cano E, del Fresno C, Sancho D, Planas A M. Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs. Cell Rep., 2020 Oct 20, Vol. 33, Issue 3; doi: 10.1016/j.celrep.2020.108291

Wenzel J, Spyropoulos D, Assmann J C, Khan M A, Stölting I, Lembrich B, Kreißig S, Ridder D A,
Isermann B, Schwaninger M. Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain. Arterioscler Thromb Vasc Biol. 2020 Oct 8; ATVBAHA120315061. doi: 10.1161/ATVBAHA.120.315061

van Oostrum M, Campbell B, Seng C, Müller M, tom Dieck S, Hammer J, Pedrioli P G A, Földy C, Tyagarajan S K, Wollscheid B. Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity. Nat Commun. 2020 Oct 5; 11(1):4990. doi: 10.1038/s41467-020-18494-6

Levard D, Buendia I, Lanquetin A, Glavan M, Vivien D, Rubio M. Filling the gaps on stroke research: Focus on inflammation and immunity. Brain Behav Immun. 2020 Oct 2. doi: 10.1016/j.bbi.2020.09.025 [Epub ahead of print]

Rolova T, Wu Y-C, Koskuvi M, Voutilainen J, Sonninen T-M, Kuusisto J, Laakso M, Hämäläinen R H, Koistinaho J, Lehtonen S. Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease. Stem Cell Res., 2020 Oct , Vol.48, 1019668; doi: 10.1016/j.scr.2020.101968

Chandel S, Sathis A, Dhar M, Giri H, Nathan A A, Reddy Samawar S K, Gupta A, Gopal J, Harish R, Mohan V, Dixit M. Hyperinsulinemia promotes endothelial inflammation via increased expression and release of Angiopoietin-2. J Atheroscler., 2020 Aug,  Vol. 307, pp. 1-10. doi:10.1016/j.artheriosclerosis.2020.06.016

Drieu A, Lanquetin A, Levard D, Glavan M, Campos F, Quenault A, Lemarchand E, Naveau M, Pitel A L, Castillo J, Vivien D, Rubio M. Alcohol exposure-induced neurovascular inflammatory priming impacts ischemic stroke and is linked with brain perivascular macrophages. JCI Insight. 2020 Feb 27; 5(4):e129226. doi: 10.1172/jci.insight.129226

Cserép C, Pósfai B, Lénárt N, Fekete R, Làszlo Z I, Lele Z, Orsolits B, Molnár G , Heindl S, Schwarcz A D, Ujvári K, Környei Z, Tóth K, Szabadits E, Sperlágh B , Baranyi M, Csiba L, Hotobágyi T, Maglóczky Z, Martinecz B, Szabó G, Erdélyi F, Szipócs R, Tamkun M M, Gesierich B, Duering M, Katona I, Liesz A, Tamás G, Dénes Á. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science, 2020 Jan 31, Vol. 367, Issue 6477, pp. 528-537, doi: 10.1126/science.aax6752

2019

Party H, Dujarrier C, Hébert M, Lenoir S, Martinez de Lizarrondo S, Delépée R, Fauchon C, Bouton M-C, Obiang P, Godefroy O, Save E, Lecardeur L, Chabry J, Vivien D, Agin V. Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments, Acta Neuropathol Commun., 2019 Oct 14, Vol. 7, Art. 153, doi:10.1186/s40478-019-0807-2